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This collection comprises materials created and collected by Eunice Caldwell Cowles. These materials consist of letters, transcripts, speeches, and photographs. One main topic of the collection is the Wheaton College Female Seminary.

The collection includes materials collected by Martha Sawyer Holmers. The collection includes letters and reports on Wheaton Seminary. The main focus of the collection is Martha Sawyer Holmes' time at Wheaton as the principal from 1842-1846.The collection spans the years of 1839-1946.